The pain of advanced pancreatic cancer makes patients physically and mentally tormented, which seriously affects the quality of life, and some people are suicidal due to fear. It is difficult to control the pain of advanced pancreatic cancer, and sometimes morphine drugs can hardly relieve the pain, and these drugs have side effects such as constipation, poor urination, nausea and vomiting, drowsiness, and even damage the immune system. EUS-CPN is particularly suitable for the treatment of abdominal pain in advanced pancreatic cancer and is a safe, efficient and economical analgesic solution for advanced pancreatic cancer. Ultrasound endoscopy-guided plexus block takes an average of 15 minutes to perform. The operation is performed by using an ultrasound endoscope to enter the subcardia, displaying an image of the abdominal aorta through the gastric wall, and finding its branch abdominal trunk artery along the abdominal aorta, with the abdominal ganglion located at the beginning of the abdominal trunk artery. Under the guidance of ultrasound gastroscopy, the abdominal ganglion is punctured with a puncture needle, and then anhydrous alcohol is injected to destroy the ganglion and achieve pain relief. If combined with radioactive iodine particle (131I) implantation, it is more effective in relieving abdominal pain caused by pancreatic cancer and can last longer. Adverse effects, such as transient diarrhea and hypotension, may occur, but recovery is usually rapid and no serious complications such as acute pancreatitis, pancreatic leakage, bleeding, perforation and abdominal infection have occurred. It has been shown that ultrasound endoscopy-guided abdominal ganglion block can relieve abdominal pain in 79% to 88% of patients, and the dose of analgesics did not increase or even decreased in 82% to 91% of patients. Pain scores were significantly reduced at 12 hours postoperatively, and the pain relief rate was 90% at 72 hours and 88% at 1 week postoperatively. Ultrasound endoscopy-guided plexus block has its unique advantages, because the posterior wall of the small curvature of the gastric body is closer to the abdominal cavity stem, which can continuously visualize the target in real time, and multispectral can distinguish the blood vessels, making the puncture more accurate. With the improvement of the corresponding instrumentation and operational techniques, ultrasound endoscopy-guided plexus block will become the main method for the treatment of pain in advanced pancreatic cancer.