A five-millimeter breast nodule with imaging suspicion of malignancy can be punctured first, and if the puncture result is unsatisfactory a biopsy can be considered. Five-millimeter breast nodules are most often found on physical examination or inadvertently, and it is rare for them to present with clinical manifestations. Currently, breast nodules are mostly screened by mammography or ultrasound. When a breast nodule is detected, the imaging report will grade the breast nodule, and biopsy is considered necessary for breast nodules of 4a and above. Generally, coarse needle aspiration is the preferred biopsy option for breast nodules. If the aspiration result is unsatisfactory and the patient is suspected to have a higher likelihood of malignancy, further options include minimally invasive biopsy after excision of the nodule or surgical excision and sending it for intraoperative freezing. For the specific treatment of five-millimeter breast nodules, consultation with a medical professional is required.