Acute pyelonephritis is a disease with a relatively high incidence, and its treatment mainly includes the following aspects: 1, active anti-infective treatment, urinary tract infections are commonly caused by Gram-negative bacilli, of which more than 85% are Escherichia coli, according to the type of pathogenic bacteria to choose sensitive antimicrobial agents, clinical commonly used quinolone antibiotics, three generations of cephalosporins and semi-synthetic penicillin, aminoglycoside 2, bed rest, pay attention to nutritional intake; 3, symptomatic treatment, should drink more water to avoid holding urine, so as not to cause further aggravation of the infection, high body temperature can be antipyretic treatment; 4, for the cause of treatment, patients with recurrent pyelonephritis, to exclude the presence of urinary stones, pay attention to lifestyle, women should pay attention to cleaning the urethral opening, etc..