Chronic pyelonephritis is usually treated with antibiotics, such as cephalosporin antibiotics and traditional Chinese medicine, which are analyzed below. The clinical manifestations of chronic pyelonephritis include intermittent episodes of urinary frequency, urgency, painful urination, lumbago or asymptomatic bacteriuria. Its treatment is generally based on urine culture and drug sensitivity tests to determine the causative agent and select the appropriate antibiotic. The commonly used antibiotics are cephalosporin antibiotics, such as ceftriaxone sodium, cefminox, cefixime, etc. Chinese herbal medicine can also be applied for treatment, and the commonly used Chinese herbal formulas are Bazheng San and Tonic Zhong Yi Qi Tang. Commonly used drugs are white foxglove, plantain, stone weed and other drugs. Generally, with the above active treatment, the condition of chronic pyelonephritis can be better controlled or even cured.