What is the cause of thick calves, mainly depends on the specific state of thick calves, as follows: 1, physiological state: if the calf thick is dominated by muscle content, these are usually physiological state, some families in the genetic aspect will show relatively thick calves, thick calves is a signal of human health, because the relative content of skeletal muscle, the blood supply to the heart will also be more. 2, pathological The reason: calf thick depends on whether there is fat accumulation or edema, fat accumulation is usually caused by obesity, if edema, we must exclude whether there is liver disease or kidney disease, resulting in malnutrition, hypoproteinemia caused by calf thick. Some patients with cardiac insufficiency may also have fluid accumulation in the lower extremities resulting in thick calves. If the calf is symmetrical, it is usually not a big problem, so follow the above clues to look for systemic problems. If it is localized, you should also be concerned if there is some subcutaneous problem.