Insulin resistance will not affect weight loss, but rather weight loss is also conducive to alleviate insulin resistance, because the mechanism of insulin resistance and obesity are very closely related, insulin action of the target organ is mainly the liver and peripheral adipocytes, skeletal muscle cells, obese people’s liver fat content is relatively high, the number of peripheral adipocytes increased significantly, hypertrophy, fat content in the muscle is relatively high, which will result in The body’s insulin secretion efficiency decreases, insulin resistance occurs, so the core mechanism of insulin resistance is obesity. Therefore, the core mechanism of the development of insulin resistance is obesity. Whether it is through diet, exercise or weight loss drugs, so that after the weight loss down insulin resistance will naturally be significantly improved.