If a female patient develops swollen feet around the age of 45, several diseases should be considered: first, endocrine metabolic diseases should be considered. For example, women at this age may have an imbalance of estrogen and progesterone secretion, and therefore may have varying degrees of sodium and water retention, resulting in swollen feet. Secondly, factors of thyroid function should be taken into account, for example, swelling of the feet accompanied by swelling of the legs can also occur in hypothyroidism. Then, if the patient has, for example, chronic renal insufficiency, there will be hypoproteinemia and large amounts of proteinuria, which will also be accompanied by swollen feet. Finally, malnutrition swelling should also be considered in female patients with very poor nutritional status. Female patients with a past history of coronary heart disease should consider the possibility of swollen feet due to heart failure at this age.