Patients wake up from sleep with swollen feet, the following reasons are common: First, acute attack of gout: patients have a long history of gout, if they drink alcohol or eat seafood recently, it can induce an acute attack of gout, resulting in acute swelling and pain in the feet when patients wake up in the morning, as well as fever, and patients can’t even walk with weight. Second, rheumatic diseases: such as rheumatoid arthritis, which can involve the ankle joint, causing acute swelling, pain, restricted movement, and even inability to bear weight, and the rheumatic series is usually positive. Patients with swollen feet after waking up from sleep should be diagnosed and treated early in order to get rapid relief of clinical symptoms. If the patient has a history of severe gout, care must be taken to avoid drinking alcohol and eating seafood to prevent acute attacks.