In recent years, folic acid supplementation during pregnancy has become a concern for pregnant women, but excessive consumption of folic acid may lead to a number of diseases in women. In a research paper published in the international journal the Journal of Endocrinology, researchers from the University of Porto and others found that women who consume too much folic acid during pregnancy may lead to obesity and diabetes in their offspring later in life; with high doses of supplements in widespread use, the researchers called for the need for The researchers call for a safe upper limit of folic acid intake for women during pregnancy. In the article, researchers studied rats that were given 20 times the recommended dose of folic acid supplements during mating, pregnancy and lactation, and then observed that the rats produced offspring that were overweight and insulin-tolerant in adulthood, and that the offspring lacked a hormone called lipocalin, which can These offspring are also deficient in a hormone called lipocalin, which helps protect against diabetes and obesity, and exhibit irregular feeding behavior, all of which are more pronounced in female offspring; on the other hand, rats that consume the recommended daily dose of folic acid tend to have healthier offspring. The right dose of folic acid can effectively reduce the risk of neural tube defects, such as spina bifida, especially in the first 10 weeks of pregnancy; the World Health Organization recommends 0.4 mg of folic acid per day for healthy pregnant women, while women with a family history of neural tube defects are recommended to consume about 10 times more than healthy pregnant women, i.e., about 5 mg of folic acid per day. However, few studies have looked at safe upper limits of folic acid intake, and some pregnant women increase their folic acid intake unintentionally; researcher Elisa Keating says that a minimum daily intake of 0.4 mg of folic acid is necessary when pregnant, and our study shows that if folic acid intake is increased during pregnancy through the consumption of fortified foods, multivitamin pills and supplements, then it is important to study folic acid. then there is a strong need to study the upper limit of safe folic acid intake. Blind consumption of folic acid during pregnancy needs to be avoided. The potential health effects of excessive folic acid intake elucidated in this study may help policy makers reconsider setting safe folic acid intake levels, and researchers will continue to investigate how folic acid affects body metabolism in rat offspring and apply the findings to human health guidance.