Clinical diabetic patients with prolonged substandard glycemic control can cause foamy urine, the appearance of foamy urine suggests the presence of positive urinary protein and diabetic nephropathy. the incidence of diabetic nephropathy in patients with type 1 diabetes mellitus is much higher than that in patients with type 2 diabetes mellitus. Diabetic patients with prolonged substandard glycemic control can cause glomerular atherosclerosis, so that urinary protein leakage increases, early manifestation of intermittent proteinuria, gradually transition to persistent proteinuria. If there is no standardized urinary protein-lowering treatment in the early stage, it can progress to massive proteinuria, renal insufficiency, and ultimately uremia. So for diabetic patients early integrated to make blood glucose, blood pressure, blood lipid control standards, while regularly monitoring urine microalbumin. If the urine protein is found positive, give early treatment to lower the urinary protein, can slow down the progress of diabetic nephropathy.