Clinical application of insulin treatment in diabetic patients have insulin application indications, mainly seen in the following cases: 1, type 1 diabetes, type 1 diabetes for pancreatic islet failure, insulin absolute lack of insulin-dependent diabetes mellitus, the need for lifelong application of insulin treatment should not be interrupted. 2, type 2 diabetes mellitus patients with a longer history of diabetes mellitus, pancreatic islet function is gradually failing, insulin absolute lack of insulin is also need to be For type 2 diabetes mellitus, there is high glucose toxicity, diabetes mellitus three more and one less obvious symptoms, accompanied by infection, surgery, traumatic stress, etc., can be a short period of time to apply insulin to control blood glucose to improve the metabolic disorders, and after the blood glucose control is stable, can be adjusted according to the results of the patient’s pancreatic function of glucose-lowering program. For obese diabetic patients with good pancreatic function, at the same time there is insulin resistance to avoid the application of insulin therapy, otherwise it can cause hyperinsulinemia aggravate the risk of obesity, the clinical application of insulin must strictly grasp the indications for insulin to avoid the abuse of insulin.