For the diagnosis of variant angina, the clinical manifestation is angina at rest, and the ECG is a transient ST-segment elevation, and the patient is often young, usually with a history of smoking, drinking, or even drug use, all of which induce coronary artery spasm and lead to resting angina. Variable angina is usually relieved by itself, and the electrocardiogram and coronary angiogram are often normal after the relief, and the diagnosis of variant angina can be determined by the above performance. In addition to smoking and alcohol cessation, calcium channel blockers, such as diltiazem and nitrates, should be given to treat coronary artery spasm and reduce the attacks of variant angina. Beta-blockers, such as betalactam, should be avoided because they may aggravate and induce spasm.