Beta-blockers are contraindicated in patients with variant angina, which are represented by bisoprolol, metoprolol, propranolol, etc. If used alone to treat variant angina, they may aggravate coronary vasospasm and, on the contrary, aggravate the uncomfortable symptoms. In addition, chemotherapy drugs or anti-anxiety and depression drugs are also recommended not to be used in patients with variant angina, as these types of drugs may aggravate coronary vasospasm. Patients with variant angina should also pay attention to lifestyle interventions and improvements, especially smoking cessation, as studies have shown that smoking is the main factor triggering coronary vasospasm in patients, and pay attention to a low-salt, low-fat diet, regular work and rest, and keep a happy mood to better prevent the re-emergence of variant angina symptoms.