If the hepatitis B surface antigen is negative without medication, you may not take any medication, but instead review the hepatitis B panel on a regular basis, as this is likely to be a sign of hepatitis B healing. However, if the hepatitis B surface antigen is negative while taking oral nucleoside analogs, but at the same time the hepatitis B surface antibody has not become positive, it is recommended to continue to take the drugs and wait until the hepatitis B surface antibody has become positive before discontinuing the use of the nucleoside analogs because it is not yet completely certain that hepatitis B is cured. If the nucleoside analogs are discontinued, there is a possibility that the hepatitis B virus DNA quantification may rise again, so if it is discontinued, the hepatitis B virus DNA quantification should be monitored, and any increase can be detected in time. If hepatitis B turns negative, it means that hepatitis B has turned from triple positive to triple negative, and you are still taking the nucleoside analogs, you can’t stop taking the drugs, because the conversion of triple positive to triple positive doesn’t mean that hepatitis B has been cured.