The so-called hazards are the bad results that may arise, commonly. These bad results are not certain to happen, but with the passage of time and the progress of the disease, anything is possible! For example, if the tympanic membrane is perforated and the middle ear is exposed to the outside world, bacterial infection will lead to repeated pus flow, and the pus will stimulate the local area, which can produce granulation, hemorrhage, and calcified plaque formation within the tympanic chamber, and also accompanied by the breeding of fungi; the epithelial layer after the perforation of the tympanic membrane may enter the tympanic chamber through the perforation and form a cholesteatoma of the middle ear; and the long-term recurring chronic inflammation is one of the risk factors for cancer of the middle ear. ……