Objective To observe the efficacy of applying vertebral body kyphoplasty for the treatment of spinal metastases. Methods A total of 76 spinal metastatic tumor lesions were treated in 29 patients, 11 were male and 18 were female, aged 30 to 82 years old, average 63.7 years old, with spinal metastases confirmed by imaging examinations (x-ray, CT and MRI) and postoperative pathology. The clinical condition was accompanied by obvious persistent bone pain, and the duration of the symptoms ranged from 1 to 18 months, with an average of 5.2 months. 29 patients were treated with vertebral body kyphoplasty for 76 spinal metastatic tumor lesions. Changes in pain intensity, pain medication use scores, and the SF-12 health status survey were examined before and after treatment. Results Surgery of 76 lesions was successfully completed in 29 patients. The patients’ pain scores decreased from 5.0 to 9.6, with a mean of (7.8±1.3) before treatment to 2.8 to 5.5, with a mean of (3.9±0.9) after treatment (P<0.01). Patients' pain medication use scores decreased from 3 to 4, mean (3.3±0.4) before treatment to 1 to 3, mean (1.9±0.8) after treatment (p<0.01). sf-12 health survey scores: -17 to -34, mean (-29.1±4.3) before treatment, -15 to -33, mean (-22.6±3.8) after treatment (p<0.05). 0.05). Postoperative follow-up ranged from 3 to 18 months, with a mean of 8.7 months, and the patients were satisfied with the improvement of pain symptoms and quality of life compared with the preoperative period. Conclusion Application of vertebral kyphoplasty for the treatment of spinal metastases can effectively relieve pain and improve patients' quality of life in later stages.