In recent years, the improvement of clinical detection methods and comprehensive cancer treatment has enabled more and more cancer patients to survive for a longer period of time, and the number of patients with bone metastasis is also on the rise. The spine is one of the most commonly affected bones, and patients with cancer spinal metastases will experience severe pain, and the growth of the tumor may compress the nerves, leading to neurological dysfunction and a serious decline in the patient’s quality of life. On the one hand, these patients are in urgent need of treatment to alleviate their symptoms and improve their quality of life. On the other hand, these patients have a shorter expected survival time, are frail, advanced in age and with underlying diseases, and are less tolerant of major orthopaedic surgeries, in addition to the fact that these patients will likely undergo further radiation or chemotherapy in the short term after surgery. In recent years, with the development of minimally invasive treatment techniques for spinal tumors represented by vertebroplasty, patients with these advanced tumors have more options for palliative care. Percutaneous Vertebroplasty (PVP) and Posterior Keratoplasty (PKP) Percutaneous Vertebroplasty eliminates pain caused by spinal instability by placing a puncture needle through the skin into the diseased vertebral body under the monitoring of imaging and injecting bone cement to restore the strength of the vertebral body and regain spinal stability. Subsequently, vertebroplasty was improved, resulting in kyphoplasty. In kyphoplasty, a balloon is inserted into the diseased vertebral body, and the height of the vertebral body is restored while the balloon is dilated, thus correcting the kyphosis of the spine, and cement is injected to restore the strength of the vertebral body. Vertebroplasty and kyphoplasty are now commonly used to control mechanical pain caused by spinal tumors. The primary indication for vertebroplasty and kyphoplasty in the treatment of cancerous spinal metastases is pain from spinal instability. There are three main forms of pain symptoms in patients with spinal tumors: local pain caused by the growth of the tumor itself; radicular pain caused by the tumor compressing the nerve roots; and axial pain caused by spinal instability after the tumor destroys the vertebral body. Bone cement stabilizes the vertebral body immediately after solidification and is therefore most effective in relieving axial pain. In addition to the mechanical stabilizing effect of bone cement on bone destruction after solidification, there are also reports showing that bone cement has an anti-tumor cytotoxic effect as well as a tumor-killing thermal effect. Although the cervical spine is less frequently accumulated in cancer spinal metastases, PVP has rarely been used in the past due to its special anatomical structure, and recent studies have shown that PVP of the cervical spine can still be safely performed by choosing the appropriate route of approach for the cervical spine. Anselmetti et al. performed PVP under local anesthesia for a patient with cervical 1 metastasis, Yoon et al. used PVP for cervical 2 metastasis, Sachs et al. performed C2 vertebroplasty for renal metastasis via oropharyngeal approach, and Huegli et al. performed C1 and C4 vertebroplasty via lateral approach under the monitoring of a new multifunctional image-guided treatment device. These reports have made cervical metastases an indication for PVP. The overall complication rate of PVP and PKP procedures is less than 10%. The most common complication is pain localized at the puncture point, mostly due to bleeding, which is common in multiple segmental treatments or metastatic lesions rich in blood supply, such as renal or thyroid cancer. The pain tends to resolve within 72 hours, and other complications include fractures of posterior vertebral structures, cement toxicity reactions, and, rarely, arachnoid cyst formation. The most publicized complication of PVP and PKP procedures is cement leakage. Cement leakage may cause space occupation in the spinal canal as well as compression of the spinal cord and nerve roots, and may lead to pulmonary embolism when the cement leaks into the paravertebral venous system. Amoretti et al. also reported a bone marrow mud embolus in the aorta following vertebroplasty in a patient with lumbar metastases from breast cancer. Although the rate of bone cement leakage is over 41%, most reports show that these leaks are asymptomatic and require no further management. It is now generally accepted that PVP and PKP procedures are a safe technique with a symptomatic complication rate of less than 3%.