This comprehensive, minimally invasive technique for the treatment of spinal metastases has been performed in our department since last year. Please excuse the length of the paper on particle implantation therapy, which can only be reported in parts due to website regulations. 125 I Radioactive particle implantation combined with vertebroplasty or vertebroplasty Currently, the treatment of spinal metastases tends to be combined. The combination of radioactive particle implantation and open surgery can complement each other, enhance the efficacy and reduce complications. Vertebroplasty is a well-established technique for the treatment of vertebral compression fractures and is also used to treat pathological compression fractures caused by spinal metastases. Vertebroplasty, developed from vertebroplasty, provides more adequate pain relief, restores vertebral body height, and reduces cement infiltration. The overall pain relief rate for spinal metastases treated with vertebroplasty and kyphoplasty was 84%. In 23 patients treated with percutaneous vertebroplasty for spinal metastases, the pain relief rate was 87%. In patients with compression fractures caused by metastases from breast cancer, the results of a 2-year follow-up study after treatment with vertebral body kyphoplasty showed significant pain relief and satisfactory recovery of spinal function. This technique has a common working channel with 125I radioactive particle implantation, eliminating the need for repeated punctures. The bone cement facilitates radioactive particle fixation, and the two techniques have synergistic effects. The results of the 6-month postoperative follow-up showed that vertebroplasty combined with 125I particle implantation provided significant pain relief, prevented aggravation of vertebral body collapse and compression fractures, and improved survival rates.