Radiation therapy can reduce tumor load and reossify destroyed vertebrae. Radiation therapy can reduce pain in more than 80% of patients. Tumors that are sensitive to radiation therapy include: lung cancer, breast cancer, prostate cancer, and lymphoma. Tumors that are not sensitive to radiation therapy include: adenocarcinoma of the gastrointestinal tract, malignant melanoma, thyroid cancer, and renal cell carcinoma. The indications for radiation therapy-based treatment of spinal metastases include: tumors sensitive to radiation therapy, stable or slowly progressing neurological symptoms, soft tissue involving the spinal canal, multi-segmental involvement of the spine, no instability of the spine, and patients who are not suitable for surgical treatment due to medical reasons.