Although antipsychotic drugs are not addictive, withdrawal reactions can occur if the drug is stopped suddenly or withdrawn too quickly after long-term application. In particular, the pharmacological mechanism of clozapine is complex, with strong anticholinergic effects, and the chance of withdrawal reactions is extremely high, and the withdrawal symptoms are numerous and serious. There are many factors affecting withdrawal reactions, and the incidence is higher in elderly patients. It is more likely to occur in women than in men, and it is more likely to occur in those who have been taking the drug for a long time, and it is more likely to occur when the drug is stopped suddenly than gradually, but it is not significantly related to the dose of the drug. Clinical manifestations of withdrawal reactions: ① Somatic symptoms: almost all patients have different degrees of somatic symptoms, in order of frequency: insomnia, anorexia, restlessness, behavioral disorders, increased heart rate, flushing, sweating, nausea, vomiting, headache, diarrhea, individual tremors, seizures, hypertension, etc. (2) Psychotic symptoms: Most of them are the reappearance of disappeared psychotic symptoms. The disease worsens, and some of them have new psychiatric symptoms. (iii) Disorders of consciousness: manifesting as disorientation, disorganized speech, fragmented hallucinations and delusions, and clueless behavior, with the characteristics of light day and heavy night, mostly in a delirious state. ④Emotional symptoms: show excitement and talk a lot, emotional irritability, impulsiveness, anxiety, depression, etc. ⑤ Delayed dyskinesia: It is the most serious extrapyramidal adverse reaction in patients on long-term treatment or withdrawal of traditional antipsychotic drugs, manifested as involuntary movements of the mouth, face, limbs and trunk, and the symptoms are often irreversible. To avoid withdrawal reactions, the following measures can be taken: 1. If a change of medication is needed, the dose should be gradually reduced and another antipsychotic should be added as soon as possible, and an anticholinergic can be used in combination. 2. If withdrawal reactions occur during drug change or withdrawal, the dose of the original drug should be increased. 3.When delirium occurs, increase the original antipsychotic drug appropriately and add small doses of atypical antipsychotics at night, such as risperidone, olanzapine, quetiapine, aripiprazole, etc. 4. Once delayed dyskinesia occurs, add vitamin E and ginkgo biloba for treatment.