With the development of society and the improvement of economic level, the incidence of diabetes has increased dramatically. Due to the lack of knowledge about diabetes and the lack of typical clinical symptoms in about 50% of type 2 diabetic patients, many type 2 diabetic patients already suffer from various chronic complications at the time of diabetes diagnosis, and diabetic lower limb vasculopathy and diabetic foot is one of them. There are currently about 150 million people with diabetes worldwide. Diabetic foot and amputation is a major complication that threatens diabetic patients. In Europe and the United States, 40% to 70% of lower limb amputations are related to diabetes. In some areas, it is even as high as 70% to 90%. In the United States, more than 50,000 diabetic amputations are performed each year. Podiatry causes tremendous suffering for many people with diabetes. The age and duration of diabetes are significantly correlated with the risk of foot ulcers and amputations. In the United States between 1989 and 1993, the amputation rate was 1.6% for diabetic patients aged 18 to 44 years; 2.4% for those aged 45 to 64 years; and 3.6% for those >65 years. Diabetic patients account for approximately 40-60% of all nontraumatic low amputations, and 85% of diabetes-related low distal amputations are preceded by the development of foot ulcers, which occur in 4-10% of patients in developed countries.