Diabetic lower extremity skin breakdown suggests infection, which may be accompanied by necrosis of the lower extremity skin tissue in severe cases. The following clinical treatment is given: 1. local debridement and disinfection, keep the local clean, avoid the application of topical ointment, because the application of topical ointment has the risk of affecting wound healing. 2. pay attention to the patient’s local skin redness, swelling, heat, pain, etc., whether there is fluid, pus, etc., if the above conditions exist, suggest the existence of bacterial infection, it is recommended to give cephalosporin antibiotic treatment, apply cephalosporin II or Cephalosporin II or III anti-infection treatment. 3. Pay attention to monitoring the patient’s blood sugar, if the patient’s blood sugar is obviously high, pay attention to timely adjustment of hypoglycemic drugs, if necessary, switch to insulin to control blood sugar, in order to better control the infection. 4. Closely observe the patient’s systemic toxicity, such as the presence of fever, chills, poor nausea, poor mental health, etc. If there is poor blood sugar control, aggravation of local infection and the emergence of systemic toxicity symptoms, it is recommended to promptly consult the Outpatient treatment in the endocrinology department will be given during the hospitalization period with standardized glucose-lowering and anti-infection treatment, and debridement treatment will be given if necessary.