If a patient wakes up in the morning with symptoms of edema, there are usually the following diseases: 1. Consider the thyroid category of endocrine metabolic diseases, in the case of hypothyroidism, hypoparathyroidism, and adrenocortical insufficiency, the patient will have clinical symptoms and reactions of swelling, edema, and peripheral weakness after waking up in the morning. 2. If the patient develops chronic renal insufficiency, especially in the case of massive proteinuria and 3. If the patient has significant cardiac insufficiency, especially in chronic heart failure, edema and swelling will also appear in the morning, but usually spread gradually from both feet, ankles, legs, and lower extremities upwards, and finally ascites and pleural fluid will appear, all of which will cause the patient to have symptoms of edema in the morning .