Atrophy of one side of the papilla and edema of the other side are usually seen in tumors or abscesses at the base of the frontal lobe of the brain, such as internal carotid artery aneurysms, olfactory groove meningiomas, meningiomas at the base of the skull in the anterior cranial recess, and craniopharyngioma. Other tumors such as internal carotid artery spindle dilation, internal carotid artery sclerosis, trauma to the anterior cranial sulcus, arachnoiditis of the anterior cranial sulcus may also cause atrophy of the optic papilla on one side and edema on the other side. As one side of the optic nerve is first atrophied due to direct compression by the tumor, later the tumor continues to grow and generates increased intracranial pressure, resulting in edema of the healthy side of the optic papilla. Cranial plain examination can make localized or qualitative diagnosis for some frontal lobe tumors, such as oligodendroglioma, which can sometimes show calcified spots, characterized by interlocking calcium spots in the form of cords, spots or clusters; astrocytoma, calcification mostly occurs in the cystic wall or body of the tumor, and the calcification shadow is mostly curved, cords, sheets or spots; ventricular meningioma, which usually occurs in the lateral ventricle, commonly has spotted calcification shadow. Calcifications of meningiomas tend to appear as large masses with high density and clear contours, with sand-grain meningioma calcifications being the most common. When frontal lobe glioma, meningioma and metastases are close to the skull, they can cause cranial resorption, thinning, destruction and defect. When frontal lobe tumors cause increased cranial pressure, there is an increase in pressure marks in the cerebral gyrus, cranial suture splitting, and alteration and displacement of the bones in the pterygoid saddle. What are the preventive methods for atrophy of one side of the papilla and edema of the other side? Primary prevention refers to health promotion and reduction of risk factors. The role of this first line of defense is to promote a healthy lifestyle in the general population and reduce exposure to harmful factors in the environment as a way to avoid cancer altogether. To the best of our knowledge, in addition to preventing carcinogens and suspected carcinogens in the air, drinking water, food and workplace, lifestyle changes such as smoking, alcohol consumption and other bad habits are all part of primary prevention. Regular hospital examination is needed. Pay attention to reasonable rest, close eyes, eat more vegetables and fruits, exercise more, use Chinese medicine to strengthen the spleen, regulate the qi and blood, adjust the mood and sleep on time, use acupuncture to adjust the method of softening and dispersing the knots and activating blood stasis, pay attention to ensure the peace of blood pressure, blood lipids and blood sugar, and exercise appropriately.