Firm non-sunken edematous plaques on the anterior tibia and foot are a diffuse form of anterior tibial mucinous edema: a diffuse firm non-sunken edematous plaque seen on the anterior tibia and foot. What causes the symptoms of hard, non-sunken edematous plaques on the anterior tibia and foot? It is now believed that the disease is a manifestation of autoimmune disease, as in hyperthyroidism with proptosis. Evidence for this includes: (1) the disease is almost always associated with diffuse hyperthyroidism, which has been recognized as an autoimmune disease; (2) LATS (long-acting thyroid-stimulating factor) may be found in the serum of those with diffuse hyperthyroidism, proptosis, and anterior tibial mucinous edema; (3) LATS is also present in anterior tibial mucinous edema fluid and biopsy specimens; (4) LATS is present in LATS is also present in the anterior tibial mucous edema fluid and biopsy specimens. However, the specific pathogenesis remains to be further investigated. The lesions are most commonly found in the anterior tibial region, starting on one side and then extending to the extensor aspect of both lower legs, with a more or less symmetrical distribution. A small number of lesions can also be seen on the hands, arms, and face, and occasionally on the trunk. The lesions are round, oblong, or irregularly rounded, swollen, firm, non-depressed plaques with clear borders under pressure. They are waxy, translucent to rose or pale red, sometimes with brown or brownish-black coloration. The surface is uneven. The hairs are also coarse and may be orange peel-like. There is often localized increased sweating and coarse black hair with light. Self-perception may be accompanied by itching or anthroposis. Hyperthyroidism and proptosis are often associated. Thyroid acromegaly is uncommon and is characterized by hyperplasia of the finger (toe) bones and the long distal periosteum, with swelling of the soft tissues on them, and a clinical presentation of bulging fingers and toes. The diagnosis is generally not difficult based on the waxy translucent plaques raised in front of the tibia, the local coarse and black exuberance of fine hair, and the presence of proptosis hyperthyroidism. Serum LATS titers are elevated. Thyroid function measurements (including basal metabolic rate, radiolucent “‘I and 1r3) often suggest hyperthyroidism. The dermis is significantly thickened due to the accumulation of mucin in the dermis, especially in the middle and lower third of the dermis. The mucin causes extensive division of collagen fiber bundles, and electron microscopy reveals stellate expansion of fibroblasts with enhanced activity within the mucin zone. Intra-damage injection of trimethoprim (de-inflammatory pine) therapy dilute de-inflammatory pine suspension with saline into a solution of 5mg/ml, and inject into the damage, 1ml per site, a total of no more than 40mg, once every 3-4 weeks; also advocate de-inflammatory pine suspension with an equal amount of hyaluronidase (1500U/ml saline) intra-damage injection, can make the damage completely subside, but stop the drug for a few months, often Recurrence, recurrence cases then this treatment is still effective.