The new epidemic has turned everyone into geeks and nerds for the sake of epidemic prevention and control. In addition to the home office, there is sufficient time to play games, do housework, exercise cooking, grab the group purchase. Cell phones, computers inevitably become a necessity for everyone’s life. During the day, after a long time using cell phones, computers, heavy housework, we do not often feel numb and sore hands, even with no strength. Many people may think that hand numbness may be cervical spine or cavity infarction problems, think it is an old problem, do not take it seriously, but after symptomatic treatment symptoms are getting worse. So, what exactly causes these hand numbness? In fact, a large part of the cause of hand numbness is the compression of peripheral nerves in the upper limbs. The peripheral nerve is significantly restricted in its path, passing through bone-fiber tunnels or across the tendon membrane and through the fascia. When these tunnels, tendon membranes, and fascia are narrowed, thickened, or adhered for various reasons, the nerve can be compressed. If this continues, the nerve conduction may become dysfunctional, or in severe cases, permanent nerve dysfunction, a phenomenon clinically known as peripheral nerve entrapment syndrome. The most common type of peripheral nerve entrapment syndrome in the upper extremity is median nerve entrapment at the wrist. The main cause of median nerve compression at the wrist is chronic injury caused by long-term overuse of the hand and wrist, chronic inflammation of the transverse carpal ligament and content tendons, and hyperplasia of the transverse carpal ligament, narrowing of the lumen is the most common cause. The age of prevalence is 30 to 60 years old, and women are 5 times more likely than men to have unilateral or bilateral onset. In women, it is usually due to long-term domestic work, such as laundry and sweater knitting. In the case of men, they may have a history of occupational disease, such as chefs, drivers, etc. Recently, there is an increasing trend of young patients, which is related to long-term use of cell phone, mouse and playing video games. Patients first feel numbness or pain in the three and a half fingers on the radial side, and have weakness in holding objects, especially in the middle finger. The symptoms are worse at night or early in the morning, and can be relieved by shaking the wrist appropriately. Examination may reveal dull sensation or hypersensitivity in the thumb, index and middle fingers, atrophy of the greater interphalangeal muscle, and weakness of the thumb to palm. The diagnosis can be initially checked by a positive Tinel’s sign and a positive wrist flexion test (aggravated numbness). Further clarification can be made by neuromyography and nerve ultrasonography after coming to the hospital. When there is numbness and pain in the hand, numbness and awakening at night, which affects work and life; finger pinprick hyperalgesia, or finger weakness and difficulty in holding things; there is atrophy of the greater interphalangeal muscle, and the thumb to palm muscle strength is weakened or those who cannot; electrophysiology clearly suggests median nerve wrist entrapment, and nerve ultrasound shows nerve swelling and ischemia. After the diagnosis is confirmed through a series of examinations, for patients with mild median nerve entrapment syndrome, they only need to reduce wrist activities, wear braces, physical therapy, and some B vitamin (B1, B12) medication to achieve the purpose of relieving symptoms, while long-term need to pay attention to hand warmth, avoid lifting heavy objects, and excessive dorsiflexion to change bad habits. For moderate or severe cases, a surgeon is needed to solve the problem through surgery.