Tetanus is usually immunized within 24 hours of injury, and usually the earlier the injection, the better the results. Tetanus is an acute infectious disease in which Clostridium tetani invades the human body from a skin or mucous membrane wound, grows and multiplies in an anoxic environment, produces toxins and causes paroxysmal muscle spasms. The disease has an acute onset and a high mortality rate, with a certain latent period, and should be immunized in a timely manner. Usually not more than 24 hours, because once the tetanus toxin combined with the nerve, the antitoxin serum has no neutralizing effect. Timely injection of tetanus antitoxin or tetanus immunoglobulin after injury can stimulate the body to produce antibodies and neutralize free tetanus toxin, shorten the course of the disease, alleviate the condition, and avoid tetanus infection. Before the use of tetanus antitoxin, an allergy test is usually required, observation for 30 minutes, if there is no abnormality, then tetanus antitoxin injection can be carried out. For allergy test with enlarged skin mound, redness, swelling, pseudo-foot sensation, etc., it is a strong positive reaction, and the use of antitoxin should be avoided, and if it is needed, desensitization injection should be used. It is recommended that injured patients be treated early and promptly to avoid delays and serious effects.