I had hepatitis B at the age of 16, and at the age of 33 (3 years ago), I developed urine protein +3, and was diagnosed with nephrotic syndrome. Because of liver damage and numbness in the hands and feet, I had to stop using Arrowhead and add hormone to 10 mg/day, which worked well. In July this year, I went to Xiangya because of liver damage and normal urine protein, and I was tested for hepatitis B virus HBV-DNA with viral replication, and I asked the nephrologist that it was okay, and I asked the infection doctor how to treat kidney disease. I’ve come a long way to get a result, so I had to give up. Because the urine protein turns negative soon after each medication, so there has been no pathology. According to your experience is this hepatitis B kidney or nephrotic syndrome? How long does it take to do pathology in your area? According to the information you provided, your condition has the following characteristics: (1) middle-aged male patient; (2) history of hepatitis B for more than 10 years, with a large amount of proteinuria and good effect of hormone treatment. (3) There are some contradictions in the application of hormones due to the replication of hepatitis B virus. According to some of the information you provided, the current clinical diagnosis: viral hepatitis B hepatitis B-associated nephritis nephrotic syndrome (secondary to hepatitis B), but need to confirm the diagnosis need to perform kidney biopsy, we do kidney biopsy here about a week or so have the results. As for the treatment, hormone is the basic drug, if there is viral replication, it needs to be applied together with anti-hepatitis B virus drugs. There are also some comprehensive treatment measures, and we have to look at your current symptoms and detailed information to determine. You can come to the hospital for a detailed examination if you have the conditions.