Adapalene gel belongs to the retinoid class of drugs and is mainly used in the treatment of acne, with anti-inflammatory and anti-epidermal keratosis effects. Adapalene Gel has a low probability of phototoxicity and photosensitivity to ultraviolet light. It is recommended to be used topically at night and avoided during the day. Adapalene Gel should be used with caution for acne patients during pregnancy and for women who are breastfeeding. The main side effect is skin irritation, which can lead to redness, dryness and peeling of the skin after a period of application. If adverse reactions are severe, reducing the number of applications or decreasing the dose of application can alleviate them. If itching and pain are still severe, it is recommended to discontinue the use of adapalene gel.