If the immune system is damaged, it will lead to a series of diseases. The most common and serious health hazards include: a. Systemic lupus erythematosus, which mainly affects women, with fever, facial erythema, joint pain and hair loss, and can endanger the kidneys, cardiovascular and nervous systems. Second, rheumatoid arthritis is common in clinical practice, mostly in middle-aged and elderly women, and patients have increasing joint damage, mostly arteritis, pericarditis, and hepatosplenomegaly. Third, male patients mostly have systemic vasculitis, mostly affecting the kidney and heart, mostly with fever, malaise and weight loss. Fourth, some women have excessive hyperplasia of skin fibrous tissue leading to scleroderma, which causes obstruction of joint movement and swallowing difficulties, and can also cause thyroid autoimmune disease and autoimmune anemia.