Hepatitis B is an infectious disease that is dangerous to human health and causes patients to have trouble in marriage, further education, going abroad and employment. Hepatitis B treatment is a top priority for patients. Today’s hepatitis B treatment has entered an era of multi-drug competition, and while patients have more choices, they are also prone to more confusion, so much so that they enter the maze of hepatitis B treatment, which affects their normal work and life. Therefore, hepatitis B patients should be alert to avoid falling into the following four major mazes of hepatitis B treatment. Labyrinth of hepatitis B treatment 1: Eagerness for success and disregard for the long term As some hepatitis B patients think that long-term treatment means a long way off, they become pessimistic and give up lightly, leading to deterioration of their condition. Likewise, many hepatitis B patients are obsessed with pursuing current indicators such as conversion to negative, and are bouncing around between various treatment modalities, causing their disease to recur, which not only destroys the original good treatment results, but also puts their easily controlled disease in a dilemma again, and brings great trouble to the follow-up treatment. The Chinese Guidelines for the Prevention and Treatment of Chronic Hepatitis B state that the overall goal of hepatitis B treatment is to suppress viral replication and delay and stop disease progression in the long term. Therefore, patients need to establish long-term treatment goals, the disease can be controlled effectively, so that they can return to normal work and school life. The key to defeating hepatitis B is to enhance doctor-patient communication, set reasonable treatment goals, and adopt an individualized treatment plan that is most suitable for the patient. Hepatitis B treatment maze two: not seeking to understand, blindly stopping some patients do not understand that hepatitis B treatment is a protracted war, blindly pursuing the discontinuation of drugs and ignore the review after discontinuation, so that the virus rebound is not controlled in time. According to the survey results of the China Hepatitis Prevention and Control Foundation, only 50% of hepatitis B patients who are receiving antiviral treatment realize that hepatitis B treatment cannot be stopped casually, and 66% of patients have interrupted treatment on their own. The characteristics of hepatitis B virus replication in liver cells determine that the clearance of hepatitis B virus is a long-term process, and the World Health Organization survey found that authoritative experts worldwide agree that control of hepatitis B virus is the only formulation that is consistent with clinical practice. What is of concern is that even after treatment to meet the discontinuation criteria proposed by Chinese and foreign hepatitis B treatment guidelines, most patients will still experience rebound of the virus after discontinuation and need to be treated again. Discontinuation of medication is only one stage in the long-term treatment of hepatitis B and needs to be done under the guidance of a physician. Discontinuing medication is not the same as stopping antiviral treatment and should not be considered the end of hepatitis B treatment. For most hepatitis B patients, the only way to control the disease and improve health status is through long-term antiviral therapy that maximally inhibits viral replication. Labyrinth of hepatitis B treatment 3: Cognitive blindness, ignoring drug resistance Drug resistance not only leads to serious clinical consequences, but also brings additional economic and time costs to patients. Moreover, when drug resistance emerges in hepatitis B patients, even if the drugs are changed and the dose is increased, they cannot get rid of the vicious cycle of drug resistance, drug change and drug resistance again, leading to accelerated virus replication and deteriorating health conditions, which not only worsens the disease but also postpones the treatment cycle indefinitely and makes the treatment burden increasing. In addition to the different chances of drug resistance, blindly stopping and reusing drugs is also one of the causes of drug resistance. Patients with hepatitis B should realize the importance of drug resistance as early as possible, listen to the doctor’s arrangement during initial treatment, carefully and persistently use drugs, and choose drugs with high resistance gene barriers and strong viral inhibitors, all of which can reduce the risk of drug resistance and guarantee sustained efficacy. Labyrinth of hepatitis B treatment IV: emphasis on treatment over life Many patients take the short-term pointer achievement in hepatitis B treatment as the only goal, and their emotions often fluctuate with the fluctuation of the pointer, with anxiety and even fear, losing confidence in normal life. The fundamental purpose of hepatitis B treatment is to serve life. While hepatitis B patients are treated with medication, they need a happy mood and a happy life. Happiness is as important as medication.