Multiple retroperitoneal lymph node enlargement is usually considered to be caused by inflammation, tumor, parasitic infection, etc. The treatment measures for different causes are different, including the application of medication and surgery. 1. Inflammation: Inflammation of the gastrointestinal tract or other systems can cause multiple retroperitoneal lymph node enlargement, which needs to be clearly diagnosed through laboratory tests, CT or MRI. After it is clear that it is caused by inflammation, antibiotics such as ceftriaxone sodium, levofloxacin and ornidazole should be actively used for treatment. 2. Malignant tumors: patients with malignant tumors, such as intestinal cancer, gastric cancer, hepatocellular carcinoma, ovarian cancer, etc., often have lymphatic metastasis leading to multiple retroperitoneal lymph node enlargement. Surgery, radiotherapy, chemotherapy and other measures should be adopted according to the primary tumor. 3. Parasitic infection: such as filariasis, schistosomiasis can cause retroperitoneal lymph node enlargement, which needs systematic anti-insect treatment, such as etanercept, praziquantel and other drugs. 4. Other: tuberculosis and hematologic diseases, such as lymphoma, leukemia can also lead to multiple lymph node enlargement. For lymph node enlargement caused by tuberculosis, it should be treated with anti-tuberculosis drugs such as isoniazid and rifampicin. In the case of lymphoma, leukemia, specific regimens should be selected for treatment after determining the typology. When there are multiple retroperitoneal lymph node enlargement, actively consult the doctor to clarify the cause of the disease and treat it at an early stage. Drugs should be applied under the guidance of a doctor.