A 50-year-old man with headache and angina palpitations in the second half of the night, improve the examination to clarify the diagnosis and then give medication or surgical treatment. Improvement of cranial CT examination, exclude brain tumor, brain hemorrhage. Surgery for brain tumor, conservative treatment for small amount of brain hemorrhage, surgery for large amount. Measure blood pressure and take antihypertensive drugs for high blood pressure, such as nifedipine controlled release tablets and amlodipine. Cranial CT is normal, blood pressure is normal, consider neurological headache can take pregabalin, carbapentin. Angina pectoris palpitations in the middle of the night, to improve the electrocardiogram, dynamic electrocardiogram, cardiac ultrasound, coronary artery CT or coronary angiography, diagnosed as a result of coronary artery disease, can take aspirin, atorvastatin treatment. If these tests are normal, consider cardiac neurosis, can take oral anti-anxiety drugs, amitriptyline, alprazolam and so on. The appearance of headache angina palpitations, must go to the hospital to check clearly after the condition of the medication.