Lung cancer is one of the malignant tumors of the respiratory tract. Patients with lung cancer rarely cough up blood in large amounts, but usually cough up blood in small amounts. When coughing blood occurs in lung cancer, treatment should be based on the amount of bleeding. When the amount of coughing up blood is small, it can be treated with hemostatic drugs, such as Yunnan Baiyao capsule, Baimei snake venom hemagglutinase, hemostatic min and hemostatic aromatic acid. In the case of more severe cases of heavy coughing up of blood, prompt medical attention is needed to avoid choking or respiratory failure due to clots obstructing the airway. After consultation, it may be necessary to stop the bleeding with the help of methods such as bronchoscopy or interventional therapy. After coughing up blood is controlled, treatment is needed to target the primary lesion of lung cancer. If patients have coughing up blood, they should take more bed rest, keep quiet and cooperate with the doctor’s treatment. Major coughing up blood is one of the critical clinical conditions, which needs to be highly valued by family members and doctors. It needs timely medical consultation, clear diagnosis and early treatment.