1, obstructive jaundice, because the tumor is located close to the end of the common bile duct, it is easy to compress or invade the bile duct, resulting in obstructive jaundice, the patient shows progressive aggravation of skin and sclera yellow staining, often accompanied by skin itching, dark urine, light stool, late stage can show clay-colored stool. 2, unexplained weight loss of more than 10% in a short period of time, if the weight loss of more than 5kg in a short period of time (3-6 months), need to pay attention to it (except for those who lose weight), this symptom is the least typical, most of the manifestations of malignant tumors in the late stage. 3. Pain in the lower back, because pancreatic cancer will invade to the abdominal nerve plexus, which in turn leads to hidden pain and discomfort in the lower back. Most of the patients think they have lumbar spine problems or lumbar muscle strain and consult orthopedics or just perform massage, which will have better effect in the short term, but the symptoms will appear again after a period of time. 4, upper abdominal discomfort, indigestion, fullness, gastroscopy is normal, mainly manifested as stomach discomfort, some people can be accompanied by indigestion, consulted in the hospital gastroenterology, gastroscopy can be manifested as superficial gastritis or erosive gastritis, etc., the symptoms can be slightly relieved after symptomatic treatment, 2-3 months later the symptoms reappeared, no significant relief after the use of drugs, then some doctors will still give patients conservative Some doctors will still give patients conservative treatment, further delaying the condition. 5.Sudden onset of diabetes or exacerbation of diabetes suggests that the function of the pancreas is damaged, and changes should be closely observed, and it is best to exclude other diseases before diagnosing as exacerbation of diabetes. 6, chronic fatty diarrhea, 3-5 times a day defecation, mostly after eating fatty food, most patients think it is dysentery or diarrhea, and after the symptoms are relieved by oral medication, they will not go to the hospital for further examination and delay the disease. 7, spontaneous attacks of pancreatitis, smokers should be doubly suspicious.