Once hypertrophic cardiomyopathy develops, early application of drugs that improve outflow tract obstruction, such as metoprolol in beta-blockers and verapamil in calcium blockers, as well as candidate drugs, such as probenecid, is required. Hypertrophic cardiomyopathy can induce the problem of heart failure and requires regular application of drugs that inhibit myocardial remodeling, such as enalapril in angiotensin-converting enzyme inhibitors and spironolactone in aldosterone receptor antagonists. If atrial fibrillation is also present, regular application of amiodarone is required to reduce the episodes of atrial fibrillation, and metoprolol can be considered to control the heart rate in permanent atrial fibrillation. If severe outflow tract obstruction occurs and the effect of medication is not effective, early surgical treatment is recommended.