Hyperresponsiveness to auditory, visual, and tactile stimuli is one of the manifestations of Krabbe’s disease. Krabbedisease was first reported in 1916 by the Danish pediatrician Krabbe, hence the name Krabbe’s disease, and is also known as infantilefamilialdiffusesclerosis, based on its clinical features, as an autosomal recessive metabolic disorder with a mutation in the 14p gene. The gene is located at 14p. The genetic defect in Krabbe disease, which causes galactosamine-beta;-galactosidase deficiency, is a genetic metabolic disorder that causes major involvement of the white matter of the brain. The prognosis of this disease is extremely poor. Infantile forms often die within 1 year of age. Late onset cases may survive until about 10 years of age. The disease is inherited as an autosomal recessive disorder with a mutation in gene 14p. The genetic defect in the affected child results in a deficiency of galactosamine-beta;-galactosidase, leading to the deposition of many galactosaminoglycans in the white matter of the brain. Differential diagnosis of hyperresponsiveness to auditory, visual, and tactile stimuli: 1. Sensitivity to sound Neurosis is a neurological disorder characterized by debilitating brain and somatic functions. It is characterized by easy excitement and fatigue, often accompanied by emotional symptoms such as tension, worry, irritability, and physiological disorders such as muscle tension pain and sleep disorders. These symptoms are not secondary to physical illness or organic brain lesions, nor are they part of any other mental disorder. However, patients may have persistent emotional tension and mental stress before the disease. 2. Hypersensitivity It is due to the effects of the lesion that stimuli must reach a strong level to be perceived. Patients can usually only perceive strong painful stimuli and warm stimuli. There is a latency period between the start of the stimulus and its perception, and the site of the stimulus and the nature and extent of the stimulus are often not correctly indicated. 3. Sensory hypersensitivity i.e. sensory enhancement. Lowered sensory threshold or strong emotional factors cause it. The clinical manifestation is that the patient reacts particularly strongly and sensitively to stimuli of general intensity and appears unbearable. Such as feeling the sun is particularly harsh, the sound is particularly harsh, the slightest touch of the skin feels painful and unbearable, etc. is. Mostly seen in thalamic or peripheral neuropathy, psychiatry is seen in neurasthenia, hysteria, hypochondria, menopausal syndrome, etc. 4, mental allergy Mental allergy is also called psychological allergy, hypersensitivity. Refers to the fact that some people have a special aversion to particular things and feel particularly uncomfortable when exposed to them. Just like an allergic person exposed to an allergen. In mild cases, the person feels bad about himself/herself; in severe cases, a paranoid pathology appears. It can cause serious mental impairment and make it difficult to live a pleasant life like a normal person.