Chromosomal abnormalities are congenital genetic disorders that can occur regardless of chromosomal abnormality and can be more serious and affect development. For example, chromosome 5 abnormalities can cause catcall syndrome, a kitten-like cry, and severe developmental delays. 45x chromosomal abnormalities can cause Turner syndrome, which is characterized by short stature, distance between the five senses, and developmental delays. 8 chromosomal abnormalities can cause brain malformations. There are also trisomy 13 and trisomy 18, which are chromosomal abnormalities that may lead to early death in severe cases.