The most prevalent chromosomal genetic disorders are the following: 1) trisomy 21, or congenital stupidity; 2) trisomy 13; and 3) trisomy 18. Chromosomal abnormal genetic disorders account for more than 50% of spontaneous abortions and stillbirths, and 1% of neonates. They are an important cause of abnormal sexual development and male and female infertility and sterility, as well as an important cause of congenital heart disease and mental retardation. With the development of chromosome banding technology, PCR technology, DNA detection technology, etc., the understanding of the relationship between chromosomal aberrations and diseases is increasing, and chromosomal diseases are increasing day by day. Comprehensive data from many countries show that about 15% of pregnancies are miscarried, half of which are caused by chromosomal abnormalities, and about 5-8% of embryos have chromosomal abnormalities. However, more than 90% have spontaneous abortion or death before birth, and the earlier the abortion, the higher the frequency of having chromosomal abnormalities.