There are many causes of chromosomal abnormalities, such as thalassemia, hemophilia, sex chromosome imbalance, etc. Some patients show a normal state but are unable to have children. If both spouses have chromosomal abnormalities when they are on the same part of the fragment, the chances of having the next generation are extremely low, and they need to be evaluated and diagnosed genetically through a hospital. Surrogacy is medically prohibited in China, except for positive eggs, and the positive eggs must be informed; the patient’s sperm donor must be done at a designated center, or designated by a sperm bank, and is double-blind.