Usually Y chromosome abnormalities cannot be treated and are congenital disorders. Microdeletions of the Y chromosome may affect male fertility. Clinically common deletions of Y chromosome region A, B, and C can affect testicular nerve function, leading to azoospermia or severe oligospermia, which in turn affects normal male fertility, but does not affect other parts of male health or sexual function. For patients with fertility requirements, IVF or other assisted reproduction methods are required to obtain offspring. If the patient has Y chromosome microdeletion resulting in azoospermia, then a surgical procedure to find sperm and then IVF is required. If Y chromosome A and B deletions occur, the probability of finding sperm is low and surgery is not recommended, in which case offspring can be obtained through sperm bank donor. In the case of Y chromosome region C deletion, sperm can be found by testicular microsperm retrieval. Usually for Y chromosome microdeletion, medication is not recommended as it is ineffective and cannot be used to change the chromosome deletion and also to improve the testicular nerve function.