I. About motherhood 1. Can I get pregnant with major and minor triplets? At present, there is no effective way to turn hepatitis B major triplet into stable minor triplet with negative DNA, so as long as the liver function is normal, both major and minor triplet can get pregnant. If you wait for the DNA to turn negative or completely negative is out of reach, and if the liver function is not normal it is very passive. Pay attention to blocking when you get pregnant. 2. Is it necessary to take hepatitis B immunoglobulin during pregnancy? This is the most controversial issue, various clinical studies have no uniform results, some say it helps, some say it does not. Non-commercial organizations do not support the injection, and most of the support is from local hospitals, perhaps due to profits. The overall conclusion is that the majority of those who recommend injections. The general opinion is that those with small triplets and negative DNA do not need to have hepatitis B globulin, and those with large triplets can consider it on their own or follow the advice of the doctor at that hospital. It is worth injecting for comfort, peace of mind and increased confidence alone. 3.Where is the key to blocking? The most critical and indisputable part of the blockade is the injection of globulin for the baby. After the baby is born, it is highly recommended that the first injection of hepatitis B immunoglobulin be given within 2 hours; the second injection of hepatitis B immunoglobulin is recommended within 15-30 days for babies born to mothers with major triplets and negative DNA, while babies born to mothers with minor triplets may not receive the second injection. There are two options for vaccination: first, the first shot is given within 24 hours of birth, followed by one shot each in January and June; second, the first shot is given 15 or 30 days after the first globulin injection, and the second and third shots are delayed according to national planning rules, such as the first shot is given on 15 days, the second shot on 45 days, and the third shot on the 15th day after half a year of age. 4. What is the mother-to-child infection rate? After blockade is performed, the success rate of blockade is about 90% for mothers with major triplets and close to 100% for those with minor triplets and negative DNA. So the total average is about 95-97% (this is the nationally recognized rate). 5.Can I breastfeed? In the case of major triple-positive, breastfeeding is possible after blockade (after the child is born with globulin and vaccine). If you have a small triplet and are DNA negative, you can rest assured. However, it is important to avoid it when the nipple is damaged. If you really feel uneasy about the big three, then artificially, as well as a smart and lovely baby. 6.Which is better for interruption: normal delivery or cesarean section? Both are the same, there is no question of which is better. Hepatitis B virus is not a factor in deciding the mode of delivery. The doctor should decide the mode of delivery according to your own condition at the time of delivery. 7.How to contact between mother and baby after birth? The best blood and saliva should not be in direct contact, such as everyone’s wounds, the mother’s blood stains, etc.. Other normal contact can be made, such as kissing the face head and feet. Please do not be nervous for contact. Even if you come in contact with body fluids, the chance of getting infected is extremely low. If we can be more careful, of course, everything will be safe. It is not possible to completely cut off contact with these body fluids, no matter how careful you are in contact with your children. 8. Is hepatitis B immunoglobulin safe? Are there any side effects? As long as it is produced by regular manufacturers are safe (and there are no underground manufacturers who can produce hepatitis B immune globulin). Theoretically, the side effects of hepatitis B immunoglobulin include: causing mutation of the virus, causing failure of vaccination of the infant, causing a burden on the kidney function of the mother, and the possibility of transmission of other diseases from the blood product. In practice, none of these have occurred, except for the failure of vaccination of the infant. 9.Does pre-term abortion increase intrauterine infection? This is one of the causes of intrauterine infection in mother and baby, but it is important to distinguish the location of the pre-eclampsia and not to worry if it is not caused by the placenta. Many pregnant women have experienced this during their pregnancy, but their children are healthy. 10.What should I do if I find abnormal liver function after pregnancy? Because of the early pregnancy reaction and the burden of the fetus on the liver, even healthy people may have abnormal liver function after pregnancy. Therefore, don’t be nervous, stay calm and relaxed, you don’t need treatment for transaminases less than 200, and you should review the situation after two weeks. Even if you have to be hospitalized, it is not a very dangerous thing, the medication prescribed by the doctor is safe. There are many pregnant women who have experienced this. There is a connection between liver function and mood, and a good mood is often better than all drugs! 11.Can’t I get pregnant if my liver function is abnormal before I get pregnant? Yes. The fetus will increase the burden on the liver after pregnancy, so there is a fear of a significant rise in liver function to the detriment of mother and child. If you have abnormal liver function before pregnancy, then it is more likely to rise further after pregnancy, which is more detrimental to the safety of pregnancy. However, there is a situation that is not in the period of medication, but the liver function has been slightly abnormal, and at this time and have to be pregnant, you can also consider pregnancy, but pay more attention to the liver function, early detection and early enzyme reduction to protect the fetus. 12.Can I get pregnant while taking lamivudine or interferon? At present, domestic and foreign data and clinical studies show that there is no evidence to prove that lamivudine is teratogenic, that is to say, there is no case that has been confirmed to be caused by taking lamivudine. However, the clinical studies on the use of Lamy for fertility have only been conducted for a few years, and there are not many studies and cases, so the majority of doctors do not recommend pregnancy under the principle of safety. If you have an unplanned pregnancy, your doctor’s attitude is usually to let you think about it, so think about it yourself. Both lamivudine and interferon have been reported to affect the fetus in animal experiments, but no adverse effects have been recorded in human clinical practice for the time being. Note: The mega dose used in animal experiments, while the human body of course uses the normal amount of drugs. 13.What tests should be done more than healthy pregnant women before and after pregnancy? Detailed liver function, ultrasound and DNA quantification should be done before pregnancy. Liver function tests should also be done in the early, middle and late stages of pregnancy. 14.Can I get pregnant when I take enzyme-lowering drugs or liver-protective drugs? There are too many enzyme-lowering drugs in the world, and some of them are counterfeit, so you should pay attention to this. Also, pay attention to the ingredients of the drug and the drug description. And consult with your doctor beforehand. About the father 1. What is the rate of paternal-infant infection? The concept of paternal-infant infection refers to infection during fetal life, rather than postnatal infection. There is very little research on father-infant infection, so we can only say that the chance is very small, so small that we can omit the calculation. But there is no guarantee that there is no, as long as the child is born after the three vaccinations required by the state, is very reassuring. Just pay attention to the contact infection after birth. At present, there is not a single case that has been proven to be a true father-infant infection. There is a view that as long as the father’s HBV-DNA at the time of pregnancy is below 100,000 times, even a very low chance of father-infant infection will not occur. 2. Should the woman be given hepatitis B immunoglobulin during pregnancy if the man is a hepatitis B carrier? No. There is no need. This is because there is no paternal-infant blockage. If, unfortunately, the infection does occur during the fetal period, it is useless to give any injection. 3. If the man is a carrier of hepatitis B virus, should the baby be given hepatitis B immunoglobulin after birth? No. The reason is the same as above. 4.How to contact between father and baby after birth? It is best not to have direct contact with blood and saliva, but other normal contact, such as kissing the face, head and feet. Please do not be nervous for contact. Even if contact with body fluids, the chances of infection are extremely low. Just we can be more careful, of course, everything is foolproof. 5.Can I have a baby if I take lamivudine or interferon? The current information and clinical studies show that there is no evidence that lamivudine can cause fetal teratogenicity when taken by the woman during pregnancy. However, the clinical study of lamivudine for fertility has only been conducted for a few years, and there are not many research time and cases, so under the principle of safety, most doctors do not recommend women to take lamivudine during pregnancy. Both Lamy and interferon have been reported to have effects on the fetus in animal studies, but no adverse effects have been recorded in human clinical practice at this time. Note: The mega-dose used in animal experiments, while the normal dose used in humans, of course. From the above can be reasoned, for the male side should be more at ease. 6.Can I have children when my liver function is abnormal? For the male partner, abnormal liver function does not affect the sperm. However, if you are taking drugs, it depends on the drug, but generally you can have children. 3. About both carriers 1. Is there any increase in the rate of infection of the fetus when both partners are carriers? Since the rate of intrauterine infection of the fetus by the father is considered almost zero, the rate of infection is still determined by the mother. 2. Will both carriers aggravate each other’s disease? No, it will not. Why some people have major triplets and some people have minor triplets? In fact, it is simply the response of the virus in the face of different immune status in the human body, for example, if your immunity is low, the virus will replicate so much that it will be major triplets, while the opposite is minor triplets DNA negative. 4. About the baby 1. Is the infection if the cord blood is positive for various things? It is not credible because the placenta is shed with the direct infiltration of the mother’s blood and the result is incorrect, and the second is that these positives are caused by the incomplete particles of the virus that enter the body from the mother’s blood through the umbilical cord during the fetal period. Whatever the positives are, they do not fully represent the intrauterine infection, and the original blocking program should still be followed after birth. 2.When should the hepatitis B immunoglobulin be given? As soon as possible after birth, it is best to finish injecting the globulin in 2 hours. Then the vaccine will be injected within 24 hours. If the baby is born to a mother with major triple-positive, consider giving an extra shot of globulin at 15 days to 1 month just in case. 3. How much hepatitis B immunoglobulin should be given? What about the vaccine? Generally, 100 units of globulin is given, but 200 units is also possible. For babies of mothers with major triplets, the vaccine can be doubled in the first or second shot, or not, don’t count too much. Because they are similar. 4.I don’t want to check my baby because I am afraid to face failure, what should I do? It is wrong to think that sooner or later you will have to face something that you cannot escape from. More importantly, suppose the child is not infected, but because your dragging does not test you do not know the situation of antibody production, so that you can not decide how to carry out antibody production or strengthen, leaving a possible infection in the future hidden danger, a loss of work is a pity. 5.When should I have a medical checkup? One month after the third vaccination, i.e. at 7 months of age, is recommended. This is the period when the antibody value is highest and the results have stabilized. 6.Where is the blood drawn for infants? Usually the cervical vessels, some are on the head or inner thighs or the back roots of the feet. It is recommended that this be done at a children’s hospital where the nurses have experience. 7.What should I do if I don’t have hepatitis B antibody? (1) You can add 1~2 doses, or re-vaccinate and increase the dose appropriately. (2) The immunization program of 0, 1, 2 and 12 months can be used. (3) Combine a small dose of interleukin-2 with hepatitis B vaccination. (4) BCG vaccine or cowpox vaccine can increase the immune response to hepatitis B vaccine and can be used together. 8.When should I get a booster vaccine? When the test results come out and the hepatitis B antibody is negative or weakly positive, you should get a booster immediately. That is, when you enter kindergarten and when you enter elementary school. 9.What is the best way to get tested in a hurry? It is generally recommended to check after 7 months of age. It is important to check early, you can use finger blood to see the negative and positive of hbsag, called “liver micro”, prick the middle finger or ear to take a drop of blood on the test paper, the results will be available in a few minutes. 10.What does it mean when the test result is 2, 5 positive or 2, 4, 5 positive? Both are healthy results, and it would be better if the result is after 6 months. There are few babies born to mothers who are carriers that are not in this situation. Generally speaking, babies born to mothers with major triplets develop antibodies and are 2 and 5 positive, while babies born to mothers with minor triplets are 2, 4 and 5 positive. These are incomplete particles of the virus that enter the body through the umbilical cord blood during fetal life. It is not scientific for some doctors to count this condition as an infection.5 or 4 or 5 will disappear naturally after a long time.