Pancreatic cancer stage 3 belongs to the middle and late stage, conservative treatment is preferred, the effect of surgery is not obvious, the prognosis of surgery is poor, and the symptoms can be improved with conservative treatment such as chemotherapy and radiotherapy. Pancreatic cancer is highly malignant, and the treatment is related to the tumor stage. If pancreatic cancer is found in early stage, if the tumor is located in the head or neck of pancreas, pancreaticoduodenectomy is feasible, and if the tumor is large, total pancreatectomy is feasible, but the prognosis is worse; in the middle-late stage, radiotherapy and chemotherapy are the mainstay, and gemcitabine can be used as the mainstay of the treatment or combined with the paclitaxel program, which can prolong the survival period to the maximum extent and reduce the pain. If patients with stage 3 pancreatic cancer have obstructive manifestations such as pancreatic fluid, bile, etc., in order to improve the symptoms, palliative surgery can be performed, which can be carried out under open or laparoscopic conditions, and it can greatly improve the quality of life. Pancreatic cancer treatment should be standardized under the guidance of professional hospitals, choose the most appropriate treatment measures to avoid delaying the best time for treatment.