HPV does not necessarily turn negative after cervical conization, which is usually related to individual’s physical condition, the degree of viral infection and other factors, and cannot be generalized. Cervical conization is a local tissue excision for cervical epithelial lesions, or cervical cancer, and is usually performed at stage II or III of cervical intraepithelial neoplasia to prevent the occurrence of cervical cancer. While HPV is the main causative agent of epithelial lesions or cervical cancer, although the tissue infected with HPV virus is removed, HPV infection may exist in the entire cervical area or in the vaginal wall, skin mucosa or other parts of the body, so HPV will not turn negative as long as HPV virus exists in other areas. In some women, due to weak resistance and immunity, even if the lesion is removed, recurrent persistent HPV infection may occur, so HPV does not easily turn negative either. However, if the patient’s body resistance is strong and the lesion is limited, HPV may turn negative after cervical conization. Therefore, 3 months after cervical conization, you should go to gynecology department to review cervical TCT and HPV to observe the specific situation. Normally, you should keep your vulva dry and clean, quit smoking and alcohol, and do not eat spicy and stimulating food.