1, cervical conization and colposcopic multi-point biopsy Once thought that the results of colposcopic multi-point biopsy and conization of the pathological results of no difference, can replace the latter, but in recent years that the two can not replace each other. First, cervical lesions are characterized by multicentricity, and the difference between a multipoint biopsy and a conization series is similar to the difference between a “point” and a “surface”. Secondly, multi-point biopsy often takes superficial material, it is difficult to judge whether there is infiltration and infiltration depth, therefore, for colposcopic biopsy report of carcinoma in situ, not except infiltration or infiltration depth is not clear, through the conization of the depth of infiltration can be judged. 2.Ordinary electric knife cervical conization, cold knife conization and LEEP Cervical conization was initially carried out by dissecting knife (i.e. cold knife conization), the advantage of which is that the edge of the cut is clear, which is conducive to pathological examination. In recent years, cervical loop electrosurgical excision (LEEP) has been widely carried out, with the advantage of simplicity and ease of use, but the adequacy of the depth of cut has been questioned, and LEEP itself has no cervical molding effect. Because of previous concerns about current damage to the cutting edge, it has not been advocated for electrosurgical conization. In recent years, it is believed that the effect of electrosurgical conization is comparable to that of cold conization, but with less bleeding. After adopting the techniques of submucosal injection of diluted epinephrine saline, controlling the power of the electric knife, vertical cutting and rapid cutting, the electric knife does not affect the observation of the cutting edge. 3, cervical conization of surgical indications: therapeutic and preventive therapeutic cervical conization of the main object is CIN2-3. for CIN1 and non-CIN lesions, generally not recommended conization. The indications for diagnostic cervical conization include: (1) Early invasive carcinoma is not excluded in cervical biopsy, in order to clarify the diagnosis and determine the scope of surgery. (2) Cytology and colposcopy are not in line with each other: malignant cells are found in cervical cytology, CIN1 or non-CIN lesions in colposcopy, cervical biopsy or segmental diagnostic scraping of cervical canal is negative; (3) atypical adenocarcinoma is found in TCT or suspected adenocarcinoma of the cervix. 4, the surgical scope of cervical conization: width and depth It is generally believed that the width of cervical conization is 0.5 cm outside the iodine discoloration area to make a circumferential incision, and the depth of conization (cone height) needs to reach 2-3 cm. In fact, the length of the cervical canal of the nonpregnant uterus is about 2 cm, and the cervical migratory zone of the cervix of the young women is more close to the cervical orifice by the influence of estrogen. Therefore, in young patients with CIN3/CIS, a cone height of 2 cm is theoretically sufficient for conization as a therapeutic goal, and some studies even suggest that a cone height of more than 1.5 cm is sufficient. For patients who are suspected of early invasive cancer, conization is mainly to provide information for follow-up treatment, and usually the treatment is not completed by conization, so it is not necessary to cut too deep; for patients who need to retain fertility, too large cone height will increase the risk of postoperative cervical insufficiency, miscarriage and preterm delivery. 5, follow-up treatment of cervical conization: comprehensive consideration The pathology of conization is the main basis for choosing the follow-up treatment, and should be combined with the patient’s age, fertility requirements, follow-up conditions, and the situation of the cutting edge: (1). For patients with CIN2 or less lesions, follow-up is sufficient. (2). For CIN3 and carcinoma in situ, if the patient is old, has poor follow-up conditions, and has no fertility requirements, total extrafascial hysterectomy is feasible; if the patient has fertility requirements and negative margins, follow-up and observation are necessary. (3). For stage Ia1 invasive carcinoma of the uterine cervix, if the patient is young or has reproductive requirements and has clean margins, follow up and promote fertility. If the margins are not clean, repeat conization can be performed to promote fertility; if the patient is old and has no reproductive requirement, total hysterectomy is feasible. (4) For patients with stage Ia2～Ib1 invasive carcinoma of the cervix, radical hysterectomy should be performed unless the patient has a very strong desire to have children, extensive hysterectomy and pelvic lymph node dissection should be performed or radiotherapy should be performed.