On the question of what causes chronic renal failure disease in children, kidney disease experts pointed out that in fact, renal insufficiency can be considered a very important cause of chronic renal failure disease in many people, which is often referred to as the azotemia period, this period is also a prelude to chronic renal failure disease in children. How is chronic renal failure disease caused? The glomerular filtration rate of patients with chronic renal failure is basically reduced to 20% to 30% of normal, and the ability to maintain the stability of the internal environment of the body of patients with chronic renal failure disease in children has been somewhat impaired, which can make patients with chronic renal failure disease in children have relatively mild azotemia, and generally some mild impairment of the kidney concentration function is often manifested as patients Patients with chronic renal failure may also have mild anemia. When children with chronic renal failure have returned to a more stable state, the blood creatinine of children with chronic renal failure is often elevated. In the case of chronic kidney failure disease in children, the renal tubules are generally hypermetabolic, and the renal tubules of the remnant kidney units, especially the proximal ones, are more hyper-metabolic, and the production of oxygen free radicals is increased, and the cells are damaged, so that the tubular interstitial lesions continue and the kidney units of the patients lose their functions. Once chronic kidney failure in children usually occurs, which may trigger the occurrence of acute renal failure disease, it is necessary for patients to immediately carry out effective treatment, pay more attention to expand blood volume, timely correction of water, electrolyte disorders and acid-base imbalance in the patient’s body, to restore to normal circulatory function. At the same time, children with chronic renal failure also need to apply some drugs that can activate blood circulation and remove blood stasis as soon as possible, which has a very positive effect on preventing the occurrence of chronic renal failure in children.