The most important thing is that it is one of the most important sexually transmitted diseases, highly contagious, with a high incidence, and in some areas the incidence accounts for 20%-31% of the total number of patients with sexually transmitted diseases, after gonorrhea, ranking second in the annual growth rate of more than 100%, more common in the south than in the north, the age of prevalence between 16 and 35 years old. The majority of patients continue to have lesions for many years, but they do not heal, so early detection and timely and effective treatment. The average incubation period is 3 months. It is mainly transmitted through sexual contact, but can also be transmitted through contaminated household utensils. Although HPV rarely causes serious health problems in men, especially those with very good immune systems. HPV infections of all types in the reproductive tract are very common in the population. It is difficult to evaluate men in detail, and no large studies have been done on men. It is assumed that more than half of all men will become infected with HPV at some point in their lives. What are the routes of HPV infection in men? Similar to women, men can become infected with HPV through intimate skin-to-skin contact, primarily through sexual intercourse (vaginal or anal). simple everyday contact, such as shaking hands, is not a way to become infected. How does HPV infection in men affect men’s health? HPV infection in men is not a disease in itself and most infections can be cleared by the body’s own immune system and do not usually cause any symptoms or affect health. Low-risk HPV viruses cause genital warts, usually around the anus, penis, scrotum, groin or thighs. Condyloma acuminatum is curable. High-risk HPV infections may cause penile or anal cancer in men (mostly in gay, bisexual or HIV-positive men), but are very rare. The theoretical basis of ALA-PDT for acromegaly: HPV infected cells are actively proliferating and ingest high concentrations of ALA; ALA is converted intracellularly into strong photosensitive PpIX; laser irradiation generates large amounts of singlet oxygen and free radicals, which attack biofilm structures at close range within the cell; the targeted killing effect is confined to the cell and therefore has a mild effect on surrounding normal cells.