Abnormal bone fibrous hyperplasia is a clinically common tumor-like lesion that is characterized by the formation of fibrous tissue and woven bone in areas of normal bone, resulting in bone fragility and susceptibility to fracture. Osteofibrodysplasia can be classified as multiple, solitary, or Albright syndrome. Multiple osteochondrodysplasia invades most bones throughout the body, often favoring one limb, and is asymmetric when bilaterally involved, and produces a variety of deformities, especially tumors occurring in the proximal femur, often resulting in a shepherd’s crook deformity. Surgery is the preferred treatment for this disease. Simple scraping and bone grafting is the commonly used clinical method, but there is a certain recurrence rate. It is very difficult to treat patients with recurrent recurrence and multiple haemorrhages clinically, and the efficacy is also unsatisfactory, often troubling orthopaedic surgeons and patients. Since 2008, the Department of Orthopedics of Jinan Military Hospital has successfully applied diphosphonates to the clinical treatment of osteochondrodysplasia based on relevant professional knowledge and advanced experience from abroad, and explored a new method of combined application of intravenous and oral drugs, and has completed the clinical treatment and observation of more than 30 patients, all of whom have achieved satisfactory clinical results.