[Abstract] Albright syndrome is a group of syndromes characterized by multiple osteochondrofibrosis, brownish skin discoloration, and precocious puberty. [The cause is unknown. It is thought to be a pathogenetic abnormality in which the mesenchymal tissue, which should be transformed into osteoblasts, is disoriented and turns into fibroblasts, leading to bone fibrosis. The lesion may be autosomal dominant, but the ectopic rate is very low and most cases are disseminated. [The fibrous tissue replaces the normal bone tissue, and the bone cortex is thinned, with no clear boundary between the osteophytes. Microscopically, there are scattered fibrous trabeculae with irregular shape, size and arrangement, which may gradually transform into lamellar bone. There may be foci of hemorrhage and multinucleated giant cell reaction in the area. [The disease progresses slowly and may stop developing after the body matures. Skeletal system: bone decalcification, fibrous degeneration, bending, and fracture. The disease mostly occurs in the long bones, craniofacial bones, starting from the maxilla and mandible, temporal bone and occipital bone, manifesting as a distended deformity of the maxillofacial region, which is painless, with displaced and loose teeth, and corresponding symptoms such as nasal congestion and protruding eyeballs when invading the maxillary sinus and orbit, etc. X-ray bone images are divided into three categories according to the amount and severity of fibrous tissue replacement in bone: single- or multiroom transillumination changes with more fibrous components; bone trabeculae frosted glass-like changes with more fibrous components; and cotton wool-like changes presenting speckled areas of increased bone density that form bone-like tissue. Skin pigmentation: Occurs between 4 months and 2 years of age as irregular brownish “milk coffee spots” on the head, sacrum, buttocks and thighs, well-defined and not elevated on the skin. Precocious puberty: It is mainly seen in female patients, who can have their first menstruation and secondary sexual characteristics before the age of 10, and some of them may conceive (true precocious puberty). Due to early skeletal maturity, the epiphysis closes early, showing faster growth in childhood and shorter stature in adulthood. Other endocrine disorders such as hyperthyroidism, acromegaly, hyperparathyroidism, and mammary gland development in men may also be present, but are less common. [The diagnosis is made by the presence of two of the three features: multiple osteochondrofibrosis, brownish skin spots and precocious puberty. When one of the three features is present, the patient should be alerted to the disease and be further examined. [For those who need surgery urgently, the principle is to correct the deformity and improve the function, and partial or total excision should be performed according to the location and size of the lesion. For extensive lesions, surgery is usually performed after maturation. Radiotherapy may lead to malignant transformation into osteosarcoma, so it is not recommended. [The prognosis is generally good, but some cases (especially those who have undergone multiple surgeries or radiotherapy) may become malignant.