Progressive ossifying fibrous dysplasia, formerly known as ossifying myositis, is a rare genetic disorder. The pathological changes in this disease are hyperplasia and abnormal calcification of soft tissues. We recently obtained some results in a patient treated with warfarin and hormones, and there was an improvement in the subcutaneous hard nodules and calcification appeared to be reduced. Warfarin can reduce the calcification of tissues, but the INR value needs to be observed, and generally a small dose is sufficient; hormone can reduce the fibrosis of tissues, with the side effect of osteoporosis, and this side effect is positive for the disease, which happens to reduce the abnormal calcification, also in small doses. The patient had no significant side effects for 1 year with the drug. Several patients have been diagnosed in the country so far, and it is recommended to use this treatment protocol as well, at a very small cost. Other diseases that present with abnormal calcification can also be tried with this treatment for skeletal muscle calcification.